In the multi-omic analysis of myeloma lesions discussed, which finding best describes the relationship between T-cell exhaustion signatures and treatment response to bispecific antibodies?
The presence of exhausted T-cells uniformly predicts resistance to bispecific antibodies
Exhausted T-cell signatures were only seen in late-stage extramedullary disease
Two lesions both showing exhaustion signatures responded differently to treatment, meaning exhaustion alone cannot reliably predict response