In patients whose absolute lymphocyte count rose above the normal range (around 3 × 10⁹/L) during cilta-cel expansion, what was observed with a single prophylactic dose of cyclophosphamide 500 mg?
It eliminated the risk of ICANS-associated parkinsonism
It did not reduce the incidence of parkinsonism, but symptoms were generally milder and more often improving or resolved at presentation
It had no effect on either the incidence or the severity of parkinsonism, similar to prophylactic dexamethasone